B-Cell Differentiation

Preferred Label : B-Cell Differentiation;

NCIt synonyms : B Lymphocyte Differentiation; B-Cell Development; B Cell Differentiation;

NCIt definition : In mammalian bone marrow, B-Cell Development consists of progressive differentiation from CD34 progenitor cells to plasma and memory B cells by positive/negative selection in response to local signals, including antigens and cytokines. B cell development begins with immunoglobulin gene somatic recombination and pre-B cell receptor expression. Antigen-induced signal transduction via BCR-associated ITAM molecules activates B cell proliferation. Further differentiation involves additional immunoglobulin gene recombination and expression. Antigen-stimulated circulating (resting) B cells proliferate and differentiate into plasma and memory B cell clones expressing immunoglobulins with the same antigen recognition site.;

Details

Origin ID

C28391;

UMLS CUI

C1511002;

Currated CISMeF NLP mapping
- B cell differentiation [GO term]
Semantic type(s)
- Cell Function [UMLS semantic type]
UMLS correspondences (same concept)
- B cell differentiation [GO term]
biological_process_has_associated_location
- Cell [NCIt concept]
biological_process_has_initiator_process
- Intercellular Communication Process [NCIt concept]
biological_process_has_result_anatomy
- B-Lymphocyte [NCIt concept]
biological_process_involves_gene_product
- AT-Hook-Containing Transcription Factor [NCIt concept]
- B-Cell Antigen Receptor Complex-Associated Protein Alpha Chain [NCIt concept]
- B-Cell Linker Protein [NCIt concept]
- CD320 Antigen [NCIt concept]
- CKLF-Like MARVEL Transmembrane Domain-Containing Protein 7 [NCIt concept]
- Fc Receptor-Like Protein 5 [NCIt concept]
- Forkhead Box Protein P1 [NCIt concept]
- G-Protein Coupled Receptor 183 [NCIt concept]
- Histone Deacetylase 9 [NCIt concept]
- ICOS Ligand [NCIt concept]
- Immunoglobulin Lambda-Like Polypeptide 1 [NCIt concept]
- Interleukin-13 [NCIt concept]
- Interleukin-4 [NCIt concept]
- Interleukin-7 [NCIt concept]
- Low Affinity Immunoglobulin Epsilon Fc Receptor [NCIt concept]
- Nonhomologous End-Joining Factor 1 [NCIt concept]
- RAS Guanyl-Releasing Protein 1 [NCIt concept]
- Single-Stranded DNA Cytosine Deaminase [NCIt concept]
- Tyrosine-Protein Kinase BTK [NCIt concept]
biological_process_is_part_of_process
- Histogenic Process [NCIt concept]
- Host Defense Mechanism [NCIt concept]
- Immune Response Process [NCIt concept]
- Immune System Process [NCIt concept]
process_includes_biological_process
- B Cell Proliferation [NCIt concept]
- Generation of Antibody Diversity [NCIt concept]
- Immunoglobulin Class Switch Recombination [NCIt concept]
process_involves_gene
- AICDA Gene [NCIt concept]
- AICDA wt Allele [NCIt concept]
- AKNA Gene [NCIt concept]
- AKNA wt Allele [NCIt concept]
- BLNK Gene [NCIt concept]
- BLNK wt Allele [NCIt concept]
- BTK Gene [NCIt concept]
- BTK wt Allele [NCIt concept]
- CD320 Gene [NCIt concept]
- CD320 wt Allele [NCIt concept]
- CD40 Gene [NCIt concept]
- CD40 wt Allele [NCIt concept]
- CD72 Gene [NCIt concept]
- CD72 wt Allele [NCIt concept]
- CD79A Gene [NCIt concept]
- CD79A wt Allele [NCIt concept]
- CMTM7 Gene [NCIt concept]
- CMTM7 wt Allele [NCIt concept]
- FCER2 Gene [NCIt concept]
- FCER2 wt Allele [NCIt concept]
- FCRL5 Gene [NCIt concept]
- FCRL5 wt Allele [NCIt concept]
- FOXP1 Gene [NCIt concept]
- FOXP1 wt Allele [NCIt concept]
- GPR183 Gene [NCIt concept]
- GPR183 wt Allele [NCIt concept]
- HDAC9 Gene [NCIt concept]
- HDAC9 wt Allele [NCIt concept]
- ICOSLG Gene [NCIt concept]
- ICOSLG wt Allele [NCIt concept]
- IGLL1 Gene [NCIt concept]
- IGLL1 wt Allele [NCIt concept]
- IL13 Gene [NCIt concept]
- IL13 wt Allele [NCIt concept]
- IL4 Gene [NCIt concept]
- IL4 wt Allele [NCIt concept]
- IL7 Gene [NCIt concept]
- IL7 wt Allele [NCIt concept]
- NHEJ1 Gene [NCIt concept]
- NHEJ1 wt Allele [NCIt concept]
- RASGRP1 Gene [NCIt concept]
- RASGRP1 wt Allele [NCIt concept]

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