E3 Ubiquitin-Protein Ligase Itchy Homolog

Preferred Label : E3 Ubiquitin-Protein Ligase Itchy Homolog;

NCIt synonyms : Itchy E3 Ubiquitin Protein Ligase Homolog; AIP4; ITCH; HECT-Type E3 Ubiquitin Transferase Itchy Homolog; Itchy E3 Ubiquitin Protein Ligase; Atrophin-1 Interacting Protein 4; EC 2.3.2.26; Atrophin-1-Interacting Protein-4; NAPP1; NFE2-Associated Polypeptide 1; Atrophin-1-Interacting Protein 4;

NCIt definition : E3 ubiquitin-protein ligase Itchy homolog (903 aa, 103 kDa) is encoded by the human ITCH gene. This protein is involved in the regulation of inflammation through the ubiquitination of inflammatory pathway proteins.;

Details

Origin ID

C176437;

UMLS CUI

C1141025;

Automatic exact mappings (from CISMeF team)
- Galactose epimerase deficiency [LOINC component]
- ITCHING [WHO-ART Included Term]
- Itch [MedDRA LLT]
- Itching [ICNP subject]
- Itching [MedDRA LLT]
- Itching (finding) [SNOMED CT concept]
- Itchy e3 ubiquitin protein ligase [OMIM gene]
- No itch (situation) [SNOMED CT concept]
- Not itching (qualifier value) [SNOMED CT concept]
- Pruritus [HPO term]
- itching [MedlinePlus Topic]
- itchy E3 ubiquitin protein ligase [HGNC gene]
- itchy E3 ubiquitin protein ligase [ORDO Gene]
- pruritus [MeSH Descriptor]
- scabies [MeSH Descriptor]
OMIM relation
- Itchy e3 ubiquitin protein ligase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- ITCH protein, human [MeSH Supplementary Concept]
- ITCH protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- ITCH Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- Ubiquitin-Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- C2 Domain [NCIt concept]
- Proline-Rich Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Calcineurin-Dependent NFAT Signaling Pathway in Lymphocytes [NCIt concept]
- Endocytosis Pathway [NCIt concept]
- Ubiquitin-mediated Proteolysis Pathway [NCIt concept]
gene_product_is_physical_part_of
- Ubiquitin Protein Ligase [NCIt concept]
gene_product_plays_role_in_biological_process
- Negative Regulation of Immunologic Factor Signaling [NCIt concept]
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]

Keyword's position in hierarchy(ies) :

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