Zinc Finger Protein 40

Preferred Label : Zinc Finger Protein 40;

NCIt synonyms : Positive Regulatory Domain II-Binding Factor 1; HIV-EP1; Schnurri-1; HIVEP1; Human Immunodeficiency Virus Type I Enhancer-Binding Protein 1; Major Histocompatibility Complex Binding Protein 1; CIRIP; Cirhin Interaction Protein; Gate Keeper of Apoptosis-Activating Protein; MBP-1; Positive Regulatory Domain II Binding Factor 1; Human Immunodeficiency Virus Type I Enhancer Binding Protein 1; PRDII-BF1; Major Histocompatibility Complex-Binding Protein 1; GAAP;

NCIt definition : Zinc finger protein 40 (2718 aa, 297 kDa) is encoded by the human HIVEP1 gene. This protein plays a role in the regulation of viral and cellular gene expression.;

NCIt note : Zinc finger protein 40 specifically binds to the DNA sequence 5'-GGGACTTTCC-3' found in the enhancer elements of viral promoters including SV40, CMV, and HIV-1 gene promoters. Related sequences are found in the enhancer elements of a number of cellular promoters, including class I MHC, interleukin-2 receptor, and interferon-beta genes. (UniProt);

Details

Origin ID

C150020;

UMLS CUI

C0084152;

Automatic exact mappings (from CISMeF team)
- Human immunodeficiency virus type 1 enhancer-binding protein 1 [OMIM gene]
- Mannose-binding lectin 2 [OMIM gene]
- Transmembrane bax inhibitor motif-containing protein 4 [OMIM gene]
OMIM relation
- Human immunodeficiency virus type 1 enhancer-binding protein 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- HIVEP1 protein, human [MeSH concept]
- HIVEP1 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- HIVEP1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Zinc-Binding, DNA-Binding Motif [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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