" /> PML wt Allele - CISMeF





Preferred Label : PML wt Allele;

NCIt synonyms : PML; Promyelocytic Leukemia, Inducer of Gene; MYL; TRIM19; Promyelocytic Leukemia Gene; RNF71; PML Nuclear Body Scaffold wt Allele;

NCIt definition : Human PML wild-type allele is located in the vicinity of 15q22 and is approximately 53 kb in length. This allele, which encodes probable transcription factor PML protein, plays a role in transcription, repair, recombination of DNA and apoptosis through the formation of specialized bodies (PML bodies) of nuclear proteins. Acute promyelocytic leukemia is associated with the translocation t(15;17)(q22;q21) of the gene and the RARA gene.;

NCIt note : The PML gene product is a nuclear matrix protein that functions in early hematopoiesis and late erythropoiesis (GeneCards).;

GenBank Accession Number : NM_002675;

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15/05/2024


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