Myeloperoxidase

Preferred Label : Myeloperoxidase;

NCIt synonyms : EC 1.11.1.7; MPO;

NCIt definition : Myeloperoxidase (745 aa, 84 kDa) is encoded by the human MPO gene. This protein is involved in the regulation of the innate host defense through the production of hypohalous acids.;

Alternative definition : CDISC: An antigen encoded by the MPO gene that regulates innate immunity through hypohalous acids production. It can be considered as an autoantigen and is commonly associated with autoimmune systemic vasculitis diseases, cystic fibrosis, COPD and other inflammatory conditions.;

NCIt note : Myeloperoxidase is synthesized as a single chain precursor that is cleaved into a light and heavy chain. The mature enzyme is a tetramer composed of 2 light chains and 2 heavy chains. (EntrezGene);

UNII : JQZ6YM58U5;

CAS number : 9003-99-0;

Détails

Origin ID

C71145;

UMLS CUI

C4742896;

OMIM relation
- Myeloperoxidase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- MPO protein, human [MeSH Supplementary Concept]
- Myeloperoxidase [LOINC component]
- Myeloperoxidase (substance) [SNOMED CT concept]
- peroxidase [MeSH Descriptor]
- peroxidase [MeSH concept]
- peroxidase [SNOMED Notion]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- MPO Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Azurophilic Granule [NCIt concept]
- Extracellular Space [NCIt concept]
- Lysosome [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Acute Myeloid Leukemia Pathway [NCIt concept]
- Drug Metabolism by Non-CYP450 Enzymes Pathway [NCIt concept]
- Phagocytosis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Antimicrobial Effect [NCIt concept]
- Host Defense Mechanism [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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