Lysosome - CISMeF

Preferred Label : Lysosome;

NCIt definition : A class of morphologically heterogeneous cytoplasmic membrane-bound vesicle in animal and plant tissues characterized by their content of a wide variety of glycoprotein hydrolytic enzymes active at an acid pH and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture serves to digest exogenous material, such as bacteria, as well as effete organelles of the cells and is supposed to be under metabolic (hormonal) control.;

Alternative definition : NCI-GLOSS: A sac-like compartment inside a cell that has enzymes that can break down cellular components that need to be destroyed.;

Codes from synonyms : CDR0000044053;

Details

Origin ID

C13253;

UMLS CUI

C0024369;

Anatomic structure is physical part of
- Cell [NCIt concept]
Associated anatomy of gene products
- ADP-Ribosylation Factor-Like Protein 8B [NCIt concept]
- BLOC-3 Complex Member HPS1 [NCIt concept]
- Beta-Galactosidase [NCIt concept]
- Beta-Glucuronidase [NCIt concept]
- Beta-Hexosaminidase Subunit Alpha [NCIt concept]
- Beta-Hexosaminidase Subunit Beta [NCIt concept]
- Cathepsin B [NCIt concept]
- Cathepsin D [NCIt concept]
- Cathepsin H [NCIt concept]
- Cathepsin K [NCIt concept]
- Cathepsin L1 [NCIt concept]
- Cathepsin L2 [NCIt concept]
- Cathepsin Z [NCIt concept]
- Ceroid-Lipofuscinosis Neuronal Protein 5 [NCIt concept]
- Dipeptidyl Peptidase 1 [NCIt concept]
- Ectopic P Granules Protein 5 Homolog [NCIt concept]
- Lysosomal Acid Lipase/Cholesteryl Ester Hydrolase [NCIt concept]
- Lysosomal Acid Phosphatase [NCIt concept]
- Lysosomal Protective Protein [NCIt concept]
- Lysosome-Associated Membrane Glycoprotein 1 [NCIt concept]
- Lysosome-Associated Membrane Glycoprotein 3 [NCIt concept]
- N-Acetylgalactosamine-6-Sulfatase [NCIt concept]
- Non-Secretory Ribonuclease [NCIt concept]
- Palmitoyl-Protein Thioesterase 1 [NCIt concept]
- Progranulin [NCIt concept]
- Proprotein Convertase Subtilisin/Kexin Type 9 [NCIt concept]
- Prosaposin [NCIt concept]
- Ras-Related GTP-Binding Protein C [NCIt concept]
- Ras-Related Protein Rab-7a [NCIt concept]
- Run Domain Beclin-1-Interacting and Cysteine-Rich Domain-Containing Protein [NCIt concept]
- Saposin-A [NCIt concept]
- Saposin-B [NCIt concept]
- Saposin-B-Val [NCIt concept]
- Saposin-C [NCIt concept]
- Saposin-D [NCIt concept]
- Sialate O-Acetylesterase [NCIt concept]
- Tartrate-Resistant Acid Phosphatase Type 5 [NCIt concept]
- Tartrate-Resistant Acid Phosphatase Type 5b [NCIt concept]
- UV Radiation Resistance-Associated Gene Protein [NCIt concept]
- Vacuolar Protein Sorting-Associated Protein 41 Homolog [NCIt concept]
Automatic exact mappings (from CISMeF team)
- Lysosome [LOINC component]
Contains anatomical structure(s)
- Azurophilic Granule [NCIt concept]
- Lumen of the Lysosome [NCIt concept]
- Membrane of the Lysosome [NCIt concept]
Currated CISMeF NLP mapping
- Lysosome (cell structure) [SNOMED CT concept]
- lysosome, nos [SNOMED Notion]
- lysosomes [MeSH Descriptor]
- lysosomes [MeSH concept]
False automatic mappings
- Lysosome [FMA entity]
- lysosome [GO term]
Semantic type(s)
- Cell Component [UMLS semantic type]
UMLS correspondences (same concept)
- Lysosome [LOINC component]
- Lysosome [FMA entity]
- Lysosome (cell structure) [SNOMED CT concept]
- lysosome [GO term]
- lysosome, nos [SNOMED Notion]
- lysosomes [MeSH concept]
- lysosomes [MeSH Descriptor]
anatomic_structure_has_location
- Cytoplasm [NCIt concept]

Keyword's position in hierarchy(ies) :

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