Prosaposin - CISMeF

Preferred Label : Prosaposin;

NCIt synonyms : PSAP; Proactivator Polypeptide;

NCIt definition : Prosaposin (524 aa, 58 kDa) is encoded by the human PSAP gene. This protein is involved in sphingolipid catabolism.;

NCIt note : Prosaposin is cleaved into the following active polypeptides saposin-A (protein A), saposin-B-Val, saposin-B (cerebroside sulfate activator, CSAct, dispersin, sphingolipid activator protein 1, SAP-1, sulfatide/GM1 activator), saposin-C (A1 activator, Co-beta-glucosidase, glucosylceramidase activator, sphingolipid activator protein 2, SAP-2), saposin-D (component C, protein C). (UniProt); The UniProt canonical sequence corresponds to the Sap-mu-0 isoform of prosaposin.;

Details

Origin ID

C106441;

UMLS CUI

C1436561;

Automatic exact mappings (from CISMeF team)
- Mitochondrial carrier homolog 1 [OMIM gene]
- Prosaposin [OMIM gene]
- Surfactant, pulmonary-associated protein a1 [OMIM gene]
- prosaposin [ORDO Gene]
- prosaposin [HGNC gene]
- saposins [MeSH Descriptor]
OMIM relation
- Prosaposin [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- PSAP protein, human [MeSH Supplementary Concept]
- PSAP protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- PSAP Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
- Lysosome [NCIt concept]
gene_product_is_element_in_pathway
- Lysosome Assembly Pathway [NCIt concept]
- Sphingolipid Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Lipid Metabolic Process [NCIt concept]
- Lipid Transport [NCIt concept]

Keyword's position in hierarchy(ies) :

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