Lysosome Assembly Pathway

Preferred Label : Lysosome Assembly Pathway;

NCIt related terms : Lysosome;

Alternative definition : KEGG: Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.;

KEGG ID : hsa04142;

Details

Origin ID

C91440;

UMLS CUI

C2984253;

Automatic exact mappings (from CISMeF team)
- Lysosome [FMA entity]
- Lysosome [LOINC component]
- Lysosome (cell structure) [SNOMED CT concept]
- lysosome [GO term]
- lysosomes [MeSH concept]
- lysosomes [MeSH Descriptor]
Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- AP-3 Complex Subunit Beta-1 [NCIt concept]
- AP-3 Complex Subunit Delta-1 [NCIt concept]
- AP-4 Complex Subunit Beta-1 [NCIt concept]
- AP-4 Complex Subunit Mu-1 [NCIt concept]
- ATP-Binding Cassette Sub-Family A Member 2 [NCIt concept]
- Acid Ceramidase [NCIt concept]
- Alpha-L-Iduronidase [NCIt concept]
- Arylsulfatase A [NCIt concept]
- Battenin [NCIt concept]
- Beta-Galactosidase [NCIt concept]
- Beta-Glucuronidase [NCIt concept]
- Beta-Hexosaminidase Subunit Alpha [NCIt concept]
- Beta-Hexosaminidase Subunit Beta [NCIt concept]
- Cathepsin B [NCIt concept]
- Cathepsin D [NCIt concept]
- Cathepsin G [NCIt concept]
- Cathepsin H [NCIt concept]
- Cathepsin K [NCIt concept]
- Cathepsin L1 [NCIt concept]
- Cathepsin L2 [NCIt concept]
- Cathepsin S [NCIt concept]
- Cathepsin Z [NCIt concept]
- Cation-Independent Mannose-6 Phosphate Receptor [NCIt concept]
- Ceroid-Lipofuscinosis Neuronal Protein 5 [NCIt concept]
- Clathrin Heavy Chain 1 [NCIt concept]
- Clathrin Heavy Chain 2 [NCIt concept]
- Cystinosin [NCIt concept]
- Dipeptidyl Peptidase 1 [NCIt concept]
- Ganglioside GM2 Activator [NCIt concept]
- Hyaluronidase-1 [NCIt concept]
- Lysosomal Acid Glucosylceramidase [NCIt concept]
- Lysosomal Acid Lipase/Cholesteryl Ester Hydrolase [NCIt concept]
- Lysosomal Acid Phosphatase [NCIt concept]
- Lysosomal Protective Protein [NCIt concept]
- Lysosomal-Associated Transmembrane Protein 5 [NCIt concept]
- Lysosome-Associated Membrane Glycoprotein 1 [NCIt concept]
- Lysosome-Associated Membrane Glycoprotein 2 [NCIt concept]
- Lysosome-Associated Membrane Glycoprotein 3 [NCIt concept]
- Major Facilitator Superfamily Domain-Containing Protein 8 [NCIt concept]
- N-Acetylgalactosamine-6-Sulfatase [NCIt concept]
- N-Acetylglucosamine-1-Phosphotransferase Subunit Gamma [NCIt concept]
- N-Acetylglucosamine-1-Phosphotransferase Subunits Alpha/Beta [NCIt concept]
- Palmitoyl-Protein Thioesterase 1 [NCIt concept]
- Prosaposin [NCIt concept]
- Sortilin [NCIt concept]
- Sphingomyelin Phosphodiesterase [NCIt concept]
- Sulfatase-Modifying Factor 1 [NCIt concept]
- Tartrate-Resistant Acid Phosphatase Type 5 [NCIt concept]
- Tartrate-Resistant Acid Phosphatase Type 5b [NCIt concept]
- V-Type Proton ATPase 116 kDa Subunit A 1 [NCIt concept]
- V-Type Proton ATPase 116 kDa Subunit A 3 [NCIt concept]
- V-Type Proton ATPase Subunit S1 [NCIt concept]
pathway_has_gene_element
- ABCA2 wt Allele [NCIt concept]
- ACP2 wt Allele [NCIt concept]
- ACP5 wt Allele [NCIt concept]
- AP3B1 wt Allele [NCIt concept]
- AP3D1 wt Allele [NCIt concept]
- AP4B1 wt Allele [NCIt concept]
- AP4M1 wt Allele [NCIt concept]
- ARSA wt Allele [NCIt concept]
- ASAH1 wt Allele [NCIt concept]
- ATP6AP1 wt Allele [NCIt concept]
- ATP6V0A1 wt Allele [NCIt concept]
- CLN3 wt Allele [NCIt concept]
- CLN5 wt Allele [NCIt concept]
- CLTC wt Allele [NCIt concept]
- CLTCL1 wt Allele [NCIt concept]
- CTNS wt Allele [NCIt concept]
- CTSA wt Allele [NCIt concept]
- CTSB wt Allele [NCIt concept]
- CTSC wt Allele [NCIt concept]
- CTSD wt Allele [NCIt concept]
- CTSG wt Allele [NCIt concept]
- CTSK wt Allele [NCIt concept]
- CTSL wt Allele [NCIt concept]
- CTSS wt Allele [NCIt concept]
- CTSV wt Allele [NCIt concept]
- GALNS wt Allele [NCIt concept]
- GBA1 wt Allele [NCIt concept]
- GLB1 wt Allele [NCIt concept]
- GM2A wt Allele [NCIt concept]
- GNPTAB wt Allele [NCIt concept]
- GNPTG wt Allele [NCIt concept]
- GUSB wt Allele [NCIt concept]
- HEXA wt Allele [NCIt concept]
- HEXB wt Allele [NCIt concept]
- HYAL1 wt Allele [NCIt concept]
- IDUA wt Allele [NCIt concept]
- IGF2R wt Allele [NCIt concept]
- LAMP1 wt Allele [NCIt concept]
- LAMP2 wt Allele [NCIt concept]
- LAMP3 wt Allele [NCIt concept]
- LAPTM5 wt Allele [NCIt concept]
- LIPA wt Allele [NCIt concept]
- MFSD8 wt Allele [NCIt concept]
- PPT1 wt Allele [NCIt concept]
- PSAP wt Allele [NCIt concept]
- SMPD1 wt Allele [NCIt concept]
- SORT1 wt Allele [NCIt concept]
- SUMF1 wt Allele [NCIt concept]
- TCIRG1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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