Lysosomal Alpha-Mannosidase

Preferred Label : Lysosomal Alpha-Mannosidase;

NCIt synonyms : Mannosidase Alpha Class 2B Member 1; Alpha-Mannosidase B; Mannosidase Alpha-B; EC 3.2.1.24; Lysosomal Alpha-D-Mannosidase; Lysosomal Acid Alpha-Mannosidase; Laman; MAN2B1;

NCIt definition : Lysosomal alpha-mannosidase (1011 aa, 114 kDa) is encoded by the human MAN2B1 gene. This protein is involved in protein deglycosylation and the processing of N-linked carbohydrates.;

NCIt note : Lysosomal alpha-mannosidase is synthesized as a single-chain precursor which is processed into 3 glycopeptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). The 70 kDa peptide is further partially proteolyzed into 3 peptides (A, B and C), which remain associated via disulfide links. (UniProt and OMIM);

NCI Metathesaurus CUI : CL1926449;

Details

Origin ID

C203758;

UMLS CUI

C5891049;

OMIM relation
- Mannosidase, alpha, class 2b, member 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- MAN2B1 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Exosome [NCIt concept]
- Extracellular Space [NCIt concept]
- Lumen of the Lysosome [NCIt concept]
- Nucleoplasm [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Glycoprotein Degradation Pathway [NCIt concept]
- Lysosome Assembly Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Carbohydrate Metabolic Process [NCIt concept]
- Catabolic Process [NCIt concept]
- Hydrolysis [NCIt concept]
- Post-Translational Modification [NCIt concept]

Keyword's position in hierarchy(ies) :

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