Acid Ceramidase

Preferred Label : Acid Ceramidase;

NCIt synonyms : PHP32; N-Acylsphingosine Amidohydrolase; Putative 32 kDa Heart Protein; AC; ACDase; EC 3.5.1.23; ASAH1; Acid CDase; Acylsphingosine Deacylase;

NCIt definition : Acid ceramidase (395 aa, 45 kDa) is encoded by the human ASAH1 gene. This protein plays a role in sphingosine biosynthesis.;

NCIt note : Acid ceramidase is processed into a heterodimer containing one alpha and one beta subunit. (UniProt);

Details

Origin ID

C103901;

UMLS CUI

C2000891;

Currated CISMeF NLP mapping
- acid ceramidase [MeSH Descriptor]
- acid ceramidase [MeSH concept]
False automatic mappings
- Acrocallosal syndrome [ORDO Disease]
- Angiotensin I-converting enzyme [OMIM Phenotype]
OMIM relation
- N-acylsphingosine amidohydrolase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- ASAH1 protein, human [MeSH Supplementary Concept]
- ASAH1 protein, human [MeSH concept]
Validated automatic mappings to NTBT
- Ceramidase (substance) [SNOMED CT concept]
- acylsphingosine deacylase [SNOMED Notion]
- ceramidases [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ASAH1 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Lumen of the Lysosome [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Ceramide Signaling Pathway PID [NCIt concept]
- Lysosome Assembly Pathway [NCIt concept]
- Phospholipid Signaling Pathway [NCIt concept]
- Sphingolipid Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Lipid Metabolic Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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