Cathepsin L1 - CISMeF

Preferred Label : Cathepsin L1;

NCIt synonyms : CTSL Protein; Major Excreted Protein; EC 3.4.22.15; MEP; CATL; CTSL; Cathepsin L; Cathepsin-L;

NCIt definition : Cathepsin L1 (333 aa, 38 kDa) is encoded by the human CTSL gene. This protein is involved in both proteolysis and immunity.;

NCIt note : Cathepsin L1 is a lysosomal cysteine protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor.; Cathepsin L1 substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. (Entrez Gene);

Details

Origin ID

C17277;

UMLS CUI

C1310906;

Currated CISMeF NLP mapping
- Cathepsin L [LOINC component]
- cathepsin L [MeSH Descriptor]
- cathepsin L [MeSH concept]
- cathepsin l [SNOMED Notion]
False automatic mappings
- Cathepsin L (substance) [SNOMED CT concept]
OMIM relation
- Cathepsin L [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CTSL protein, human [MeSH Supplementary Concept]
- CTSL protein, human [MeSH concept]
- Cathepsin L [LOINC component]
- Cathepsin L (substance) [SNOMED CT concept]
- cathepsin L [MeSH concept]
- cathepsin L [MeSH Descriptor]
- cathepsin l [SNOMED Notion]
concept_is_in_subset
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- CTSL Gene [NCIt concept]
- Cysteine Peptidase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Lysosome [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_biomarker_type
- Metastasis and Aggressiveness Marker [NCIt concept]
gene_product_is_element_in_pathway
- Antigen Processing and Presentation Pathway [NCIt concept]
- Lysosome Assembly Pathway [NCIt concept]
- Phagocytosis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Protein Turnover [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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