Arylsulfatase B

Preferred Label : Arylsulfatase B;

NCIt synonyms : ASB; EC 3.1.6.12; ARSB; G4S; N-Acetylgalactosamine-4-Sulfatase;

NCIt definition : Arylsulfatase B (533 aa, 60 kDa) is encoded by the human ARSB gene. This protein plays a role in the removal of sulfate groups from chondroitin-4-sulfate.;

NCIt note : Convertion of the cysteine at residue 91 of arylsulfatase B to 3-oxoalanine (also known as C-formylglycine, FGly) is critical for enzymatic catalytic activity. Mutation of the SUMF1 gene results in misprocessing all sulfatases leading to multiple sulfatase deficiency. (UniProt);

Détails

Origin ID

C215308;

OMIM relation
- Arylsulfatase b [OMIM gene]
gene_encodes_gene_product
- ARSB Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Azurophilic Granule [NCIt concept]
- Lumen of the Lysosome [NCIt concept]
gene_product_has_biochemical_function
- Hydrolase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Glycosaminoglycan Degradation Pathway [NCIt concept]
- Lysosome Assembly Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Carbohydrate Metabolic Process [NCIt concept]
- Catabolic Process [NCIt concept]
- Cell Surface Extension [NCIt concept]
- Cellular Migration Process [NCIt concept]
- Hydrolysis [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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