Dipeptidyl Peptidase 1

Preferred Label : Dipeptidyl Peptidase 1;

NCIt synonyms : Dipeptidyl Peptidase I; Dipeptidyl Transferase; EC 3.4.14.1; Cathepsin C; DPP-I; CTSC; DPPI; Cathepsin J; Dipeptidyl-Peptidase I;

NCIt definition : Dipeptidyl peptidase 1 (463 aa, 52 kDa) is encoded by the human CTSC gene. This protein is involved in exo- and endo-dipeptidylpeptidase activity.;

NCIt note : Dipeptidyl peptidase 1 is processed into a mature proteolytically active enzyme consisting of a heavy chain, a light chain, and a propeptide that remains associated with the active enzyme (called the exclusion domain chain). Unlike other cathepsins that are active as monomers, dipeptidyl peptidase 1 is a 200 kDa tetramer, where the 4 subunits are heterotrimers that contain the one light chain, one heavy chain and one exclusion domain chain. (OMIM and UniProt);

Details

Origin ID

C200303;

OMIM relation
- Cathepsin C [OMIM gene]
gene_encodes_gene_product
- CTSC Gene [NCIt concept]
- Cysteine Peptidase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Lysosome [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Apoptosis Regulation Pathway [NCIt concept]
- Lysosome Assembly Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Proteolysis [NCIt concept]
- Proteolytic Processing [NCIt concept]

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