N4-(N-Acetyl-Beta-Glucosaminyl)-L-Asparagine Amidase

Preferred Label : N4-(N-Acetyl-Beta-Glucosaminyl)-L-Asparagine Amidase;

NCIt synonyms : N(4)-(Beta-N-Acetylglucosaminyl)-L-Asparaginase; EC 3.5.1.26; Aspartylglucosaminidase; AGA; Glycosylasparaginase;

NCIt definition : N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase (346 aa, 37 kDa) is encoded by the human AGA gene. This protein plays a role in the cleavage of the bond between N-acetylglucosamine and asparagine in glycoproteins.;

NCIt note : N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase is synthesized as a proprotein that undergoes autocatalytic cleavage yielding the mature alpha and beta chains. The N-terminal threonine of the beta subunit is required for nucleophile hydrolase activity. (UniProt);

Details

Origin ID

C213928;

OMIM relation
- Aspartylglucosaminidase [OMIM gene]
gene_encodes_gene_product
- AGA Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Lysosome [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Glycoprotein Degradation Pathway [NCIt concept]
- Lysosome Assembly Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Asparagine Metabolic Process [NCIt concept]
- Hydrolysis [NCIt concept]
- Post-Translational Regulation [NCIt concept]

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