Ganglioside GM2 Activator

Preferred Label : Ganglioside GM2 Activator;

NCIt synonyms : Cerebroside Sulfate Activator Protein; GM2-AP; GM2A; GM2-Activator Protein; GM2 Ganglioside Activator Protein; Sphingolipid Activator Protein 3; SAP-3;

NCIt definition : Ganglioside GM2 activator (193 aa, 21 kDa) is encoded by the human GM2A gene. This protein is involved in intermembrane cholesterol transfer and binding to gangliosides.;

NCIt note : Ganglioside GM2 activator extracts ganglioside GM2 and glycolipid GA2 from membranes and presents them as soluble forms that can be cleaved by beta-hexosaminidase isozyme A.;

Details

Origin ID

C201694;

OMIM relation
- Gm2 activator [OMIM gene]
gene_encodes_gene_product
- GM2A Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
- Lumen of the Lysosome [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
gene_product_is_element_in_pathway
- Lysosome Assembly Pathway [NCIt concept]
- Sphingolipid Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Ligand Binding [NCIt concept]
- Lipid Metabolic Process [NCIt concept]
- Lipid Transport [NCIt concept]
- Transport Process [NCIt concept]

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