Tartrate-Resistant Acid Phosphatase Type 5b

Preferred Label : Tartrate-Resistant Acid Phosphatase Type 5b;

NCIt synonyms : TRACP-5b; EC 3.1.3.2; Tartrate-Resistant Acid Phosphatase-5b;

NCIt definition : Tartrate-resistant acid phosphatase type 5b (325 aa, 37 kDa) is encoded by the human ACP5 gene. This protein is involved in acid phosphatase activity and is comprised of two disulfide linked polypeptides which are the result of proteolytic cleavage of the tartrate-resistant acid phosphatase type 5 protein.;

NCIt note : Tartrate-resistant acid phosphatase type 5b is predominantly secreted by osteoclasts and is a potential marker for both bone resorption and bone metastasis. (http://www.intermedico.com/userfiles/file/products/chemistry/IDS/trapwp.pdf);

Details

Origin ID

C99185;

UMLS CUI

C3274595;

OMIM relation
- Phosphatase, acid, type 5, tartrate-resistant [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ACP5 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Phosphatase Family Gene [NCIt concept]
gene_product_expressed_in_tissue
- Osteoclast [NCIt concept]
gene_product_has_associated_anatomy
- Lysosome [NCIt concept]
gene_product_has_biochemical_function
- Esterase [NCIt concept]
- Hydrolase [NCIt concept]
gene_product_has_chemical_classification
- Metalloprotein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Lysosome Assembly Pathway [NCIt concept]
- Riboflavin Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Bone Remodeling [NCIt concept]
- Dephosphorylation [NCIt concept]
- Hydrolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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