Lysosomal Acid Lipase/Cholesteryl Ester Hydrolase

Preferred Label : Lysosomal Acid Lipase/Cholesteryl Ester Hydrolase;

NCIt synonyms : LIPA; Sterol Esterase; Lysosomal Acid Lipase; LAL; Cholesterol Ester Hydrolase; EC 3.1.1.13; Cholesteryl Esterase; Lipase A; Acid Cholesteryl Ester Hydrolase;

NCIt definition : Lysosomal acid lipase/cholesteryl ester hydrolase (399 aa, 45 kDa) is encoded by the human LIPA gene. This protein is involved in the deacylation of low density lipoprotein core lipids to generate free fatty acids and cholesterol.;

Détails

Origin ID

C188897;

UMLS CUI

C1609787;

Automatic exact mappings (from CISMeF team)
- Cholesterol esterase [LOINC component]
- Lipase [MedDRA Preferred Term]
- Lipase a, lysosomal acid [OMIM gene]
- Lysosomal acid lipase [LOINC component]
- Triacylglycerol lipase [LOINC component]
- Triacylglycerol lipase (substance) [SNOMED CT concept]
- lipase [medical devices type]
- lipase [MeSH concept]
- lipase [MeSH Descriptor]
- lipase A, lysosomal acid type [ORDO Gene]
- lipase A, lysosomal acid type [HGNC gene]
- lipoate synthase activity [GO term]
- sterol esterase [MeSH concept]
- sterol esterase [MeSH Descriptor]
OMIM relation
- Lipase a, lysosomal acid [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- LIPA protein, human [MeSH Supplementary Concept]
- LIPA protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- LIPA Gene [NCIt concept]
gene_product_has_associated_anatomy
- Lysosome [NCIt concept]
gene_product_has_biochemical_function
- Hydrolase [NCIt concept]
- Lipase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Lysosome Assembly Pathway [NCIt concept]
- Sterol Biosynthesis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cholesterol Homeostasis [NCIt concept]
- Fatty Acid Metabolism [NCIt concept]
- Hydrolysis [NCIt concept]
- Steroid Metabolic Process [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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