Cation-Independent Mannose-6 Phosphate Receptor

Preferred Label : Cation-Independent Mannose-6 Phosphate Receptor;

NCIt synonyms : IGF2R; Insulin-Like Growth Factor-2 Receptor; MPR 300; M6PR; CI Man-6-P Receptor; Antigen CD222; Insulin-Like Growth Factor II Receptor; M6P/IGF2R; IGF-II Receptor; CD222; Insulin-Like Growth Factor 2 Receptor; 300 kDa Mannose 6-Phosphate Receptor; CI-MPR; M6P/IGF2 Receptor; CD222 Antigen;

NCIt definition : Cation-independent mannose-6-phosphate receptor (2491 aa, 274 kDa) is encoded by the human IGF2R gene. This protein is involved in receptor-mediated endocytosis.;

NCIt note : IGF2R is a 250kDa transmembrane protein. It was originally identified as a receptor for IGFII and M6P-containing proteins (e.g. lysosomal hydrolases). Lysosomal enzymes are sorted to lysosomes via IGF2R either from the Golgi, where the enzymes acquire M6P, or from the extracellular space. The majority of IGF2R molecules are located intracellularly, only 5-10% is present on the cell membrane. IGF2R is also a receptor for TGFbeta latency associated peptide (LAP), proliferin and may bind several molecules independently of M6P, including plasminogen, CD87 or retinoic acid. It is involved in activation of latent TGFbeta. It is a putative hepatocellular tumor suppressor. (from LocusLink);

Details

Origin ID

C26253;

UMLS CUI

C1334189;

Automatic exact mappings (from CISMeF team)
- CD 222 [MeSH Supplementary Concept]
- Insulin-like growth factor II receptor [OMIM gene]
- Mannose 6-phosphate receptor, cation-dependent [OMIM gene]
- insulin like growth factor 2 receptor [HGNC gene]
- receptor, igf type 2 [MeSH Descriptor]
OMIM relation
- Insulin-like growth factor II receptor [OMIM gene]
Semantic type(s)
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- IGF2R protein, human [MeSH Supplementary Concept]
- receptor, IGF type 2 [MeSH concept]
- receptor, igf type 2 [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Growth Factor Receptor Gene [NCIt concept]
- IGF2R Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Lysosome Assembly Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation Regulatory Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Mediated Endocytosis [NCIt concept]
- Receptor Signaling [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]

Keyword's position in hierarchy(ies) :

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