Progranulin - CISMeF

Preferred Label : Progranulin;

NCIt synonyms : Proepithelin; PEPI; PC Cell-Derived Growth Factor; PGRN; PCDGF; Glycoprotein 88; Glycoprotein of 88 kDa; Granulin Precursor; GRN; Epithelin Precursor; GP88;

NCIt related terms : Granulins;

NCIt definition : Progranulin (593 aa, 64 kDa) is encoded by the human GRN gene. This protein is involved in lysosome acidification, inflammation and wound healing.;

NCIt note : Progranulin can be cleaved to form at least 8 active molecules paragranulin, granulin-1 (granulin G), granulin-2 (granulin F), granulin-3 (granulin B; epithelin-2), granulin-4 (granulin A; epithelin-1) granulin-5 (granulin C), granulin-6 (granulin D) and granulin-7 (granulin E). (UniProt);

Details

Origin ID

C101403;

UMLS CUI

C1453193;

OMIM relation
- Granulin precursor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- GRN protein, human [MeSH concept]
- GRN protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Gene [NCIt concept]
- GRN Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
- Lysosome [NCIt concept]
gene_product_has_biochemical_function
- Growth Factor [NCIt concept]
gene_product_is_element_in_pathway
- Wound Repair Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation Regulatory Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Inflammatory Response [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Wound Repair [NCIt concept]
is_target
- Anti-Progranulin Monoclonal Antibody AG01 [NCIt concept]

Keyword's position in hierarchy(ies) :

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