Preferred Label : Anti-Progranulin Monoclonal Antibody AG01;
NCIt synonyms : Anti-PGRN Monoclonal Antibody AG01; Anti-GP88 Monoclonal Antibody AG01; Anti-glycoprotein 88 Monoclonal Antibody AG01;
NCIt definition : A monoclonal antibody targeting human progranulin (PGRN; glycoprotein 88; GP88), with
potential antineoplastic activity. Upon administration, anti-PGRN monoclonal antibody
AG01 targets and binds to PGRN expressed on tumor cells. This neutralizes PGRN and
prevents the activation of downstream signaling pathways, which may include extracellular
signal-regulated kinases 1 (ERK1) and 2 (ERK2), phosphatidylinositol 3-kinase (PI3K),
and focal adhesion kinase (FAK), thereby inhibiting tumor cell proliferation, migration
and invasion. PGRN, an autocrine growth factor overexpressed in various types of cancers,
plays an important role in tumorigenesis, tumor cell proliferation and invasiveness,
and drug resistance.;
Molecule name : AG-01; AG 01;
NCI Metathesaurus CUI : CL1906237;
Origin ID : C199309;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
