Saposin-C - CISMeF

Preferred Label : Saposin-C;

NCIt synonyms : Saposin C; SAP2; Sphingolipid Activator Protein-2; Glucosylceramidase Activator; Sphingolipid Activator Protein 2; SAPC; A1 Activator; Co-beta-Glucosidase; SAP-2;

NCIt definition : Saposin-C (80 aa, 9 kDa) is encoded by the human PSAP gene. This protein plays a role in binding to beta-glucosylceramidase and beta-galactosylceramidase to promote the hydrolysis of glucosylceramide and galactosylceramide, respectively.;

NCIt note : Saposin-C is comprised of amino acids 311 - 390 of prosaposin.;

NCI Metathesaurus CUI : CL1779350;

Details

Origin ID

C186554;

UMLS CUI

C5575472;

Automatic exact mappings (from CISMeF team)
- Prosaposin [OMIM gene]
- glucosylceramidase activity [GO term]
- prosaposin [ORDO Gene]
- prosaposin [HGNC gene]
- saposin C [MeSH concept]
- saposins [MeSH Descriptor]
OMIM relation
- Prosaposin [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- PSAP Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_associated_anatomy
- Lysosome [NCIt concept]
gene_product_is_element_in_pathway
- Sphingolipid Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Lipid Metabolic Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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