Saposin-B - CISMeF

Preferred Label : Saposin-B;

NCIt synonyms : Cerebroside Sulfate Activator; Sulfatide/GM1 Activator; Saposin B; SAP1; Sphingolipid Activator Protein-1; Sphingolipid Activator Protein 1; SAPB; CSAct; SAP-1; Dispersin;

NCIt definition : Saposin-B (79 aa, 9 kDa) is encoded by the human PSAP gene. This protein is involved in promoting the hydrolysis of galacto-cerebroside sulfate, GM1 gangliosides and globotriaosylceramide by arylsulfatase A, beta-galactosidase and alpha-galactosidase A, respectively.;

NCIt note : Saposin-B is comprised of amino acids 195 - 273 of prosaposin.;

NCI Metathesaurus CUI : CL1778816;

Details

Origin ID

C186551;

UMLS CUI

C5575471;

Automatic exact mappings (from CISMeF team)
- Elk4, ets-domain protein [OMIM gene]
- Prosaposin [OMIM gene]
- prosaposin [ORDO Gene]
- prosaposin [HGNC gene]
- saposin B [MeSH concept]
- saposins [MeSH Descriptor]
OMIM relation
- Prosaposin [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- PSAP Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_associated_anatomy
- Lysosome [NCIt concept]
gene_product_is_element_in_pathway
- Sphingolipid Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Lipid Metabolic Process [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients