Serine/Threonine-Protein Kinase Pim-2

Preferred Label : Serine/Threonine-Protein Kinase Pim-2;

NCIt synonyms : Serine/Threonine Protein Kinase Pim-2; PIM2; EC 2.7.11.1; Pim-2h;

NCIt definition : Serine/threonine-protein kinase pim-2 (311 aa, 34 kDa) is encoded by the human PIM2 gene. This protein plays a role in apoptosis regulation, protein phosphorylation and cell proliferation.;

Details

Origin ID

C104800;

UMLS CUI

C1453189;

Automatic exact mappings (from CISMeF team)
- Pim2 protooncogene, serine/threonine kinase [OMIM gene]
OMIM relation
- Pim2 protooncogene, serine/threonine kinase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- PIM2 protein, human [MeSH concept]
- PIM2 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- PIM2 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Acute Myeloid Leukemia Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Autophagy [NCIt concept]
- Cell Cycle Regulation Process [NCIt concept]
- G1/S Transition Checkpoint [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Negative Regulation of Apoptosis [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- PIM Kinase Inhibitor LGH447 [NCIt concept]
- PIM Kinase Inhibitor SGI-1776 [NCIt concept]
- PIM Kinase Inhibitor TP-3654 [NCIt concept]
- PIM/FLT3 Kinase Inhibitor SEL24 [NCIt concept]
- Uzansertib [NCIt concept]
- pan-PIM Kinase Inhibitor AZD1208 [NCIt concept]
- pan-PIM Kinase Inhibitor GDC-0570 [NCIt concept]
- pan-PIM Kinase Inhibitor NVP-LGB-321 [NCIt concept]

Keyword's position in hierarchy(ies) :

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