NCIt definition : An orally available, second-generation and selective ATP-competitive inhibitor of
proviral integration site for Moloney murine leukemia virus (PIM) kinases, with potential
antineoplastic activity. Upon oral administration, PIM kinase inhibitor TP-3654 selectively
binds to and prevents the activation of the PIM kinases. This prevents the activation
of PIM-mediated signaling pathways and inhibits proliferation in cells that overexpress
PIM. PIMs, constitutively active proto-oncogenic serine/threonine kinases, are upregulated
in various types of cancers and play key roles in tumor cell proliferation and survival.;
UNII : EOB0N7BOY4;
InChIKey : XRNVABDYQLHODA-JCNLHEQBSA-N;
CAS number : 1361951-15-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1361951-15-6
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G-SRS /a ;
Molecule name : TP 3654; SGI-9481; TP-3654; SGI 9481;
Semantic type(s)