NCIt definition : An orally available, second-generation and selective ATP-competitive inhibitor of
proviral integration site for Moloney murine leukemia virus (PIM) kinases, with potential
antineoplastic activity. Upon oral administration, nuvisertib selectively binds to
and prevents the activation of the PIM kinases. This prevents the activation of PIM-mediated
signaling pathways and inhibits proliferation in cells that overexpress PIM. PIMs,
constitutively active proto-oncogenic serine/threonine kinases, are upregulated in
various types of cancers and play key roles in tumor cell proliferation and survival.;
UNII : EOB0N7BOY4;
InChIKey : XRNVABDYQLHODA-JCNLHEQBSA-N;
CAS number : 1361951-15-6;
Molecule name : TP 3654; SGI-9481; TP-3654; SGI 9481;
Semantic type(s)