Preferred Label : pan-PIM Kinase Inhibitor GDC-0570;
NCIt synonyms : pan-PIM Kinase Inhibitor NB004;
NCIt definition : An orally available small molecule pan-inhibitor of the PIM serine/threonine kinase
family, with potential antineoplastic activity. Upon oral administration, pan-PIM
kinase inhibitor GDC-0570 binds to and prevents the activation of the three PIM family
kinases, PIM1, PIM2 and PIM3. This prevents the activation of PIM-mediated signaling
pathways and inhibits proliferation in cells that overexpress PIMs. PIMs, constitutively
active proto-oncogenic serine/threonine kinases upregulated in various types of cancers,
play key roles in tumor cell proliferation and survival.;
Molecule name : GDC 0570; GDC-0570; NB-004; NB 004;
Origin ID : C201209;
concept_is_in_subset
- has_target
