Preferred Label : Uzansertib;
NCIt synonyms : Pan-PIM Kinase Inhibitor INCB053914; Pan-PIM Inhibitor INCB053914;
NCIt definition : An orally available, small molecule and selective ATP-competitive pan-inhibitor of
proviral integration sites for Moloney murine leukemia virus (PIM) kinases, with potential
antineoplastic activity. Upon oral administration, uzansertib binds to and inhibits
the activities of the three PIM isoforms, PIM1, PIM2 and PIM3. This prevents phosphorylation
of their downstream targets and inhibits proliferation in cells that overexpress PIMs.
PIMs, constitutively active proto-oncogenic serine/threonine kinases upregulated in
various types of cancers, play key roles in tumor cell proliferation and survival.;
UNII : 0237X8153Q;
InChIKey : PTORCEYGCGXHDH-OVMXCRKPSA-N;
CAS number : 1620012-39-6;
Molecule name : INCB053914; INCB 053914; INCB53914;
NCI Metathesaurus CUI : CL502606;
Origin ID : C124226;
UMLS CUI : C5418172;
Semantic type(s)
- concept_is_in_subset
- has_target
