NCIt definition : An orally available, small molecule inhibitor of PIM kinases with potential antineoplastic
activity. Pan-PIM kinase inhibitor AZD1208 inhibits the activities of PIM1, PIM2 and
PIM3 serine/threonine kinases, which may result in the interruption of the G1/S phase
cell cycle transition, thereby causing cell cycle arrest and inducing apoptosis in
cells that overexpress PIMs. The growth inhibition of several leukemia cell lines
by this agent is correlated with the expression levels of PIM1, which is the substrate
of STAT transcription factors. PIM kinases are downstream effectors of many cytokine
and growth factor signaling pathways and are upregulated in various malignancies.;
Semantic type(s)