NCIt definition : A small-molecule pan-PIM protein kinase inhibitor with potential antineoplastic activity.
PIM kinase inhibitor SGI-1776 binds to and inhibits the activities of PIM-1, -2 and
-3 serine/threonine kinases, which may result in the interruption of the G1/S phase
cell cycle transition, the expression of pro-apoptotic Bcl2 proteins and tumor cell
apoptosis. PIM kinases play key roles in cell cycle progression and apoptosis inhibition
and may be overexpressed in various malignancies.;
Semantic type(s)