NCIt definition : A small-molecule pan-PIM protein kinase inhibitor with potential antineoplastic activity.
PIM kinase inhibitor SGI-1776 binds to and inhibits the activities of PIM-1, -2 and
-3 serine/threonine kinases, which may result in the interruption of the G1/S phase
cell cycle transition, the expression of pro-apoptotic Bcl2 proteins and tumor cell
apoptosis. PIM kinases play key roles in cell cycle progression and apoptosis inhibition
and may be overexpressed in various malignancies.;
UNII : 72AUA0603W;
CAS number : 1025065-69-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1025065-69-3
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G-SRS /a ;
Semantic type(s)