PIM Kinase Inhibitor SGI-1776

Preferred Label : PIM Kinase Inhibitor SGI-1776;

NCIt related terms : SGI-1776;

NCIt definition : A small-molecule pan-PIM protein kinase inhibitor with potential antineoplastic activity. PIM kinase inhibitor SGI-1776 binds to and inhibits the activities of PIM-1, -2 and -3 serine/threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition, the expression of pro-apoptotic Bcl2 proteins and tumor cell apoptosis. PIM kinases play key roles in cell cycle progression and apoptosis inhibition and may be overexpressed in various malignancies.;

UNII : 72AUA0603W;

CAS number : 1025065-69-3;

Molecule name : SGI-1776;

Details

Origin ID

C82404;

UMLS CUI

C2742218;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- SGI 1776 [MeSH concept]
- SGI 1776 [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Serine/Threonine-Protein Kinase Pim-1 [NCIt concept]
- Serine/Threonine-Protein Kinase Pim-2 [NCIt concept]
- Serine/Threonine-Protein Kinase Pim-3 [NCIt concept]

Keyword's position in hierarchy(ies) :

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