PIM1 wt Allele

Preferred Label : PIM1 wt Allele;

NCIt synonyms : Provirus Insertion Site Gene-1; PIM-1 Oncogene wt Allele; PIM; Pim-1 Oncogene (Proviral Integration Site 1) Gene; Proto-Oncogene Serine/Threonine-Protein Kinase Pim-1 Gene; Pim-1 Proto-Oncogene, Serine/Threonine Kinase wt Allele;

NCIt definition : Human PIM1 wild-type allele is located in the vicinity of 6p21.2 and is approximately 5 kb in length. This allele, which encodes proto-oncogene serine/threonine-protein kinase Pim-1 protein, plays a role in the proliferation and survival of blood cells. The PIM1 gene is overexpressed in hematopoietic malignancies such as chronic myeloid leukemia and acute lymphocytic leukemia.;

NCIt note : Overexpression of the PIM1 gene is associated with the development and progression of prostate cancer.;

GenBank Accession Number : NM_002648;

Details

Origin ID

C51255;

UMLS CUI

C1709403;

OMIM relation
- Oncogene pim 1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 6p21.2 [NCIt concept]
gene_is_element_in_pathway
- Acute Myeloid Leukemia Pathway [NCIt concept]
- Calcineurin-Dependent NFAT Signaling Pathway in Lymphocytes [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
gene_plays_role_in_process
- Hematopoietic Process [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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