Preferred Label : Azacitidine;
NCIt synonyms : 4-Amino-1-beta-D-ribofuranosyl-1,3,5-triazin-2(1H)-one; Azacytidine; 5-Azacytidine; 5-Aza-cytidine; Ladakamycin; 5-AZC; 5-Azacitidine;
NCIt related terms : 5 AZC; Mylosar; Vidaza; Azacytidine, 5-; 5-AC;
NCIt definition : A pyrimidine nucleoside analogue of cytidine with antineoplastic activity. Azacitidine
is incorporated into DNA, where it reversibly inhibits DNA methyltransferase, thereby
blocking DNA methylation. Hypomethylation of DNA by azacitidine may activate tumor
suppressor genes silenced by hypermethylation, resulting in an antitumor effect. This
agent is also incorporated into RNA, thereby disrupting normal RNA function and impairing
tRNA cytosine-5-methyltransferase activity. (NCI04);
Alternative definition : NCI-GLOSS: A drug that is used to treat myelodysplastic syndromes and is being studied
in the treatment of other types of cancer. It belongs to the family of drugs called
antimetabolites.;
UNII : M801H13NRU;
InChIKey : NMUSYJAQQFHJEW-KVTDHHQDSA-N;
CAS number : 320-67-2;
Drug name : Vidaza;
Molecule name : U-18496;
Chemical formula : C8H12N4O5;
NSC code : 102816;
ChEBI ID : CHEBI:2038;
Codes from synonyms : NSC0102816; CDR0000507584; CDR0000507586; CDR0000045177; 56;
Origin ID : C288;
UMLS CUI : C0004475;
False automatic mappings
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
https://pgtmsite.files.wordpress.com/2024/01/5-azacitidine_ad_protocole_versionfinale_site-public_20150720.pdf
2015
Canada
drug information
ECOG Performance Status 5
Agreement Score 5
Fear Score 5
Phase V Trial
Current Reformed Smoker, Years Unknown
Death Related to Adverse Event
Gleason Grade Group 5
Clinical Status Ordinal Scale Outcome 5
Upset Score 5
azacitidine
Thought Score 5
Severity of Symptom Score 5
Azacitidine
Loss of Chromosome 5
Neck Pain Score 5
Illness Intrusiveness Rating 5
Intensity and Distress 5
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https://pgtmsite.files.wordpress.com/2024/01/5-azacitidine_ad_version-finale_site-public_20151112.pdf
2015
Canada
drug information
Gleason Grade Group 5
Thought Score 5
Agreement Score 5
Phase V Trial
Death Related to Adverse Event
Use
Severity of Symptom Score 5
myelodysplasia
Illness Intrusiveness Rating 5
Loss of Chromosome 5
Intensity and Distress 5
myelodysplastic syndromes
NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology
Analyzed
Analysis
Adult Myelodysplastic Syndrome
Clinical Status Ordinal Scale Outcome 5
Fear Score 5
Childhood Myelodysplastic Syndrome
Identifier
Description
azacitidine
Azacitidine
ECOG Performance Status 5
Current Reformed Smoker, Years Unknown
Neck Pain Score 5
Upset Score 5
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https://pgtmsite.files.wordpress.com/2024/01/azacitidine_es_20120430.pdf
2012
Canada
drug information
myelodysplastic syndromes
leukaemia
Adult Acute Myeloid Leukemia
Treat
Childhood Myelodysplastic Syndrome
During Treatment
Myelodysplastic Syndrome Acute Myeloid Leukemia
Childhood Acute Myeloid Leukemia
Treatment Study
Therapy Object
NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology
Biomaterial Treatment
Adult Myelodysplastic Syndrome
AML Lab Table
Treatment Epoch
NCI CTEP SDC Acute Myeloid Leukemia Sub-Category Terminology
Azacitidine
leukemia, myeloid, acute
Acute Myeloid Leukemia without Maturation
On Treatment
GDC Treatment Frequency Terminology
Acute Myeloid Leukemia with KMT2A Rearrangement
azacitidine
Treatment
No Treatment for Diabetes
Acute Myeloid Leukemia Pathway
myelodysplasia
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