" /> DNA Methyltransferase - CISMeF





Preferred Label : DNA Methyltransferase;

NCIt synonyms : DNA-Methyltransferase; DNA Modification Methylase; Dnmt; Site-Specific DNA-methyltransferase; DNA MTase;

NCIt related terms : DNA methylase;

NCIt definition : DNA Methyltransferases are a subclass of transferase enzymes that catalyze the transfer of a methyl group from a donor compound to DNA.;

Alternative definition : NCI-GLOSS: An enzyme (a protein that speeds up chemical reactions in the body) that attaches a methyl group to DNA. A methyl group is a chemical group containing one carbon and three hydrogen molecules.;

NCIt note : An enzyme that binds to specific DNA sequences and protects the nucleotides therein. The nucleotide sequence contains a cognate recognition sequence that is protected from digestion by exonucleases. The enzyme protects the sequence by methylation on an adenine or cytosine residue. If the DNA is left unprotected, it will be proteolytically cleaved by host endonucleases.; DNA methyltransferases are categorized into three different IUBMB Enzyme Classes based on their chemical reaction products: m6A (EC 2.1.1.72) generate N6-methyladenine, m4C (EC 2.1.1.113) generate N4-methylcytosine and m5C (EC 2.1.1.37) generate C5-methylcytosine.;

Codes from synonyms : CDR0000576489; CDR0000561397;

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31/07/2025


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