Decitabine - CISMeF

Preferred Label : Decitabine;

NCIt synonyms : 2'-Deoxy-5-azacytidine; 5-Aza-2-deoxycytidine; Dezocitidine; Deoxyazacytidine; 4-Amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one; 5-Aza-2'deoxycytidine; 5-Azadeoxycytidine; Decitabine for Injection;

NCIt related terms : 5-Aza-2'-deoxycytidine; Dacogen;

NCIt definition : A cytidine antimetabolite analogue with potential antineoplastic activity. Decitabine incorporates into DNA and inhibits DNA methyltransferase, resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. (NCI04);

Alternative definition : NCI-GLOSS: A drug that is used to treat myelodysplastic syndromes and is being studied in the treatment of other types of cancer. It is a type of antimetabolite.;

UNII : 776B62CQ27;

InChIKey : XAUDJQYHKZQPEU-KVQBGUIXSA-N;

CAS number : 2353-33-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2353-33-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Dacogen;

Chemical formula : C8H12N4O4;

NSC code : 127716;

ChEBI ID : CHEBI:50131;

Codes from synonyms : NSC0127716; 00810; CDR0000508667; CDR0000045208; 145;

Details

Origin ID

C981;

UMLS CUI

C0049065;

Automatic exact mappings (from CISMeF team)
- Decitabine [ICD-11 Extension code]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 4-amino-1-(2-deoxy-.beta.-d-erythro-pentofuranosyl)-1,3,5-triazin-2(1h)-one [Substance BNPC]
- Decitabine [MeSH Descriptor]
- Decitabine (substance) [SNOMED CT concept]
- Product containing decitabine (medicinal product) [SNOMED CT concept]
- decitabine [ATC Code]
- decitabine [International Nonproprietary Name]
- decitabine [MeSH concept]
Validated automatic mappings to BTNT
- decitabine [ATC Code]
chemical_or_drug_affects_gene_product
- DNA Methyltransferase [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
- Nucleoside Analogue Incorporation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- DNA Methylation Inhibition [NCIt concept]
- Negative Regulation of S Phase [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_target
- DNA [NCIt concept]
- DNA Methyltransferase [NCIt concept]
is_component_of_chemotherapy_regimen
- Amsacrine/Decitabine [NCIt concept]
- Busulfan/Cyclophosphamide/Decitabine [NCIt concept]
- Cisplatin/Decitabine [NCIt concept]
- Cyclophosphamide/Decitabine/Doxorubicin [NCIt concept]
- Decitabine Regimen [NCIt concept]
- Decitabine/FR901228 [NCIt concept]
- Decitabine/Idarubicin [NCIt concept]
- Decitabine/Imatinib Mesylate [NCIt concept]
- Decitabine/Ruxolitinib Regimen [NCIt concept]
- Decitabine/Sorafenib Regimen [NCIt concept]
- Decitabine/Valproic Acid [NCIt concept]
- Decitabine/Venetoclax Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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