NCIt definition : The sodium salt form of guadecitabine, a dinucleotide antimetabolite composed of a
decitabine linked via phosphodiester bond to a deoxyguanosine, with potential antineoplastic
activity. Following metabolic activation via cleavage of the phosphodiester bond and
incorporation of the decitabine moiety into DNA, guadecitabine inhibits DNA methyltransferase,
thereby causing non-specific, genome-wide hypomethylation, and induction of cell cycle
arrest at S-phase. This agent is resistant to cytidine deaminase, which may result
in gradual release of decitabine both extra- and intra-cellularly, leading to prolonged
exposure to decitabine.;
UNII : 0RB89YH367;
InChIKey : XLHBNJPXFOZFNJ-BYKQGDNKSA-M;
CAS number : 929904-85-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 929904-85-8
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Semantic type(s)