" /> Guadecitabine Sodium - CISMeF





Preferred Label : Guadecitabine Sodium;

NCIt definition : The sodium salt form of guadecitabine, a dinucleotide antimetabolite composed of a decitabine linked via phosphodiester bond to a deoxyguanosine, with potential antineoplastic activity. Following metabolic activation via cleavage of the phosphodiester bond and incorporation of the decitabine moiety into DNA, guadecitabine inhibits DNA methyltransferase, thereby causing non-specific, genome-wide hypomethylation, and induction of cell cycle arrest at S-phase. This agent is resistant to cytidine deaminase, which may result in gradual release of decitabine both extra- and intra-cellularly, leading to prolonged exposure to decitabine.;

UNII : 0RB89YH367;

InChIKey : XLHBNJPXFOZFNJ-BYKQGDNKSA-M;

CAS number : 929904-85-8;

NCI Metathesaurus CUI : CL971684;

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10/05/2025


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