Guadecitabine - CISMeF

Preferred Label : Guadecitabine;

NCIt synonyms : DNMT inhibitor SGI-110;

NCIt definition : A dinucleotide antimetabolite composed of a decitabine linked via phosphodiester bond to a deoxyguanosine, with potential antineoplastic activity. Following metabolic activation via cleavage of the phosphodiester bond and incorporation of the decitabine moiety into DNA, guadecitabine inhibits DNA methyltransferase, thereby causing non-specific, genome-wide hypomethylation, and induction of cell cycle arrest at S-phase. This agent is resistant to cytidine deaminase, which may result in gradual release of decitabine both extra- and intra-cellularly, leading to prolonged exposure to decitabine.;

UNII : 2KT4YN1DP7;

InChIKey : GUWXKKAWLCENJA-WGWHJZDNSA-N;

CAS number : 929901-49-5;

Molecule name : S110; SGI-110; SGI 110;

Codes from synonyms : 252;

Details

Origin ID

C95209;

UMLS CUI

C3899005;

Currated CISMeF NLP mapping
- guadecitabine [MeSH Supplementary Concept]
- guadecitabine [MeSH concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- guadecitabine [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Guadecitabine Sodium [NCIt concept]
has_target
- DNA Methyltransferase [NCIt concept]
is_free_acid_or_base_form_of
- Guadecitabine Sodium [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients