Preferred Label : DNA modification methylases;
MeSH definition : Enzymes that are part of the restriction-modification systems. They are responsible
for producing a species-characteristic methylation pattern, on either adenine or cytosine
residues, in a specific short base sequence in the host cell's own DNA. This methylated
sequence will occur many times in the host-cell DNA and remain intact for the lifetime
of the cell. Any DNA from another species which gains entry into a living cell and
lacks the characteristic methylation pattern will be recognized by the restriction
endonucleases of similar specificity and destroyed by cleavage. Most have been studied
in bacterial systems, but a few have been found in eukaryotic organisms.;
MeSH synonym : methylases, dna modification; methylases, modification; methyltransferases, dna modification; modification methylases, dna; modification methylases; dna modification methyltransferases; modification methyltransferases, dna;
Registry Number MeSH : EC 2.1.1.-;
Wikipedia link : https://en.wikipedia.org/wiki/Dna modification methylases;
Is substance : O;
Origin ID : D015254;
UMLS CUI : C0012873;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Indexing information
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- Semantic type(s)
- UMLS correspondences (same concept)
Enzymes that are part of the restriction-modification systems. They are responsible
for producing a species-characteristic methylation pattern, on either adenine or cytosine
residues, in a specific short base sequence in the host cell's own DNA. This methylated
sequence will occur many times in the host-cell DNA and remain intact for the lifetime
of the cell. Any DNA from another species which gains entry into a living cell and
lacks the characteristic methylation pattern will be recognized by the restriction
endonucleases of similar specificity and destroyed by cleavage. Most have been studied
in bacterial systems, but a few have been found in eukaryotic organisms.
