Dihydro-5-Azacytidine

Preferred Label : Dihydro-5-Azacytidine;

NCIt synonyms : 5,6-dihydro-5-azacytidine HCl; 1,3,5-triazin-2(1H)-one, 4-amino-3, 6-dihydro-1-beta-D-ribofuranosyl monohydrochloride; 5,6-dihydro-5-azacytidine hydrochloride; DHAC;

NCIt related terms : 5,6-DIHYDRO-5-AZACYTIDINE;

NCIt definition : A synthetic nucleoside analogue of deoxycytidine. Dihydro-5-azacytidine inhibits DNA methyltransferase, thereby interfering with abnormal DNA methylation patterns that are associated with genetic instability in some tumor cells. Inhibition of this enzyme may restore expression of tumor-suppressor genes and result in antitumor activity. (NCI04);

UNII : 0627D8VG1C;

InChIKey : LJIRBXZDQGQUOO-KVTDHHQDSA-N;

CAS number : 62488-57-7;

Chemical formula : C8H14N4O5;

NSC code : 264880;

Codes from synonyms : NSC0264880;

Details

Origin ID

C980;

UMLS CUI

C0048906;

Automatic exact mappings (from CISMeF team)
- 2'-deoxy-2'-(hydroxylamino)cytidine [MeSH Supplementary Concept]
- 3'-deoxy-3'-(hydroxylamino)cytidine [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- 5,6-dihydro-5-azacytidine [MeSH Supplementary Concept]
- 5,6-dihydro-5-azacytidine [MeSH concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 5,6-dihydro-5-azacytidine [MeSH concept]
- 5,6-dihydro-5-azacytidine [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- 5,6-dihydro-5-azacytidine hydrochloride [MeSH concept]
chemical_or_drug_affects_gene_product
- DNA Methyltransferase [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- DNA Methylation Inhibition [NCIt concept]
- DNA Synthesis Inhibition [NCIt concept]
- Gene Regulation Process [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- DNA Methyltransferase [NCIt concept]
is_component_of_chemotherapy_regimen
- Cisplatin/Dihydro-5-Azacytidine [NCIt concept]

Keyword's position in hierarchy(ies) :

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