Hydralazine Hydrochloride

Preferred Label : Hydralazine Hydrochloride;

NCIt synonyms : Hydralazine;

NCIt related terms : Apressin; Apresoline;

NCIt definition : The hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydralazine alters intracellular calcium release and interferes with smooth muscle cell calcium influx, resulting in arterial vasodilatation. This agent also inhibits the phosphorylation of myosin protein and chelation of trace metals required for smooth muscle contraction, resulting in an increase in heart rate, stroke volume and cardiac output. In addition to its cardiovascular effects, hydralazine inhibits DNA methyltransferase, which may result in inhibition of DNA methylation in tumor cells.;

UNII : FD171B778Y;

InChIKey : ZUXNZUWOTSUBMN-UHFFFAOYSA-N;

CAS number : 304-20-1;

Drug name : Apresoline;

Chemical formula : C8H8N4.HCl;

NSC code : 89394;

ChEBI ID : CHEBI:31672;

Codes from synonyms : NSC0126699; 00916;

Details

Origin ID

C551;

UMLS CUI

C0282198;

Automatic exact mappings (from CISMeF team)
- Hydralazine [ICHI extension code]
- Product containing hydralazine (medicinal product) [SNOMED CT concept]
- hydralazine [ATC Code]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Hydralazine Hydrochloride [MeSH concept]
- Hydralazine hydrochloride (substance) [SNOMED CT concept]
- hydralazine hydrochloride [Substance BNPC]
- hydralazine hydrochloride [SNOMED Notion]
Validated automatic mappings to BTNT
- Hydralazine mono-Hydrochloride [MeSH concept]
Validated automatic mappings to NTBT
- Hydralazine [ICD-11 Extension code]
- Hydralazine (substance) [SNOMED CT concept]
- hydrALAZINE [LOINC component]
- hydralazine [SNOMED Notion]
- hydralazine [MeSH Descriptor]
- hydralazine [Substance BNPC]
- hydralazine [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Hydralazine [NCIt concept]
has_target
- DNA Methyltransferase [NCIt concept]
is_component_of_chemotherapy_regimen
- Hydralazine/Interferon Alfa [NCIt concept]
is_salt_form_of
- Hydralazine [NCIt concept]

Keyword's position in hierarchy(ies) :

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