Acute Myeloid Leukemia with KMT2A Rearrangement

Preferred Label : Acute Myeloid Leukemia with KMT2A Rearrangement;

NCIt synonyms : Acute Myeloid Leukemia with MLLr; Acute Myeloid Leukemia with KMT2A/MLL Rearrangement; Acute Myeloid Leukemia with 11q23 Abnormalities; Acute Myeloid Leukemia, MLL;

NCIt related terms : Acute myeloid leukemia, 11q23 abnormalities; Acute Myeloid Leukemia with MLL Rearrangement;

NCIt definition : An acute myeloid leukemia characterized by rearrangement of the KMT2A gene. It affects infants, children and adults. It is usually associated with poor prognosis.;

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL1407773;

Details

Origin ID

C174129;

UMLS CUI

C1292775;

Automatic exact mappings (from CISMeF team)
- Acute myeloid leukemia [ORDO Disease]
- leukemia, myeloid, acute [MeSH Descriptor]
Currated CISMeF NLP mapping
- Acute myeloid leukemia with 11q23 abnormalities [ORDO Disease]
- Acute myeloid leukemia with 11q23 abnormality (disorder) [SNOMED CT concept]
- Acute myeloid leukemia with 11q23-abnormality [ICD-10 Sub-category]
- Acute myeloid leukemia with KMT2A rearrangement (morphologic abnormality) [SNOMED CT concept]
- Acute myeloid leukemia, 11q23 abnormalities [ICD-O code]
Disease excludes abnormal cell
- Neoplastic Lymphoblast [NCIt concept]
Disease excludes normal cell origin
- Lymphocyte [NCIt concept]
Disease may have findings
- Hypercellular Bone Marrow [NCIt concept]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Has cytogenetic abnormalities
- Chromosomal Rearrangement [NCIt concept]
See also inter- (CISMeF)
- Acute myeloid leukemia with t(9:11)(p22;q23); MLLT3-MLL (disorder) [SNOMED CT concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Acute myeloid leukemia with 11q23 abnormalities [ORDO Disease]
- Acute myeloid leukemia with 11q23 abnormality (disorder) [SNOMED CT concept]
- Acute myeloid leukemia with 11q23-abnormality [ICD-10 Sub-category]
- Acute myeloid leukemia with KMT2A rearrangement (morphologic abnormality) [SNOMED CT concept]
- Acute myeloid leukemia, 11q23 abnormalities [ICD-O code]
concept_is_in_subset
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology Terminology [NCIt concept]
- Mapped ICDO3.1 Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology Terminology [NCIt concept]
- Mapped ICDO3.2 Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Chronic Clinical Course [NCIt concept]
- Cytogenetic Abnormalities Not Detected [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_has_abnormal_cell
- Leukemic Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloblast [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
disease_has_finding
- Blasts 10 Percent or More of Bone Marrow Nucleated Cells [NCIt concept]
- Blasts 10 Percent or More of Peripheral Blood White Cells [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Recurrent Genetic Abnormalities Present [NCIt concept]
disease_has_molecular_abnormality
- Fusion Protein Expression [NCIt concept]
- KMT2A Gene Rearrangement [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Multipotent Bone Marrow Stem Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_mapped_to_gene
- KMT2A Gene [NCIt concept]
pathogenesis_of_disease_involves_gene
- KMT2A Gene [NCIt concept]
- KMT2A wt Allele [NCIt concept]

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