KMT2A Gene Rearrangement

Preferred Label : KMT2A Gene Rearrangement;

NCIt synonyms : Myeloid/Lymphoid or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Gene Rearrangement; Lysine (K)-Specific Methyltransferase 2A Gene Rearrangement; KMT2A Rearrangement; Myeloid/Lymphoid Leukemia Gene Rearrangement; Mixed Lineage Leukemia Gene Rearrangement; Myeloid/Lymphoid or Mixed Lineage Leukemia Gene Rearrangement; Lysine Methyltransferase 2A Gene Rearrangement;

NCIt related terms : MLL; KMT2Ar; MLL Rearrangement; MLL Gene Rearrangement;

NCIt definition : A molecular abnormality indicating rearrangement of the KMT2A (MLL) gene.;

Alternative definition : NICHD: A molecular abnormality indicating rearrangement of the MLL gene. MLL gene rearrangements occur in approximately 20% of children with acute myeloid leukemia.;

Details

Origin ID

C122623;

UMLS CUI

C1506987;

Automatic exact mappings (from CISMeF team)
- Lysine-specific methyltransferase 2a [OMIM Phenotype]
- MLL gene rearrangements [LOINC component]
Semantic type(s)
- Cell or Molecular Dysfunction [UMLS semantic type]
UMLS correspondences (same concept)
- MLL gene rearrangements [LOINC component]
concept_is_in_subset
- AML Authorized Value Terminology [NCIt concept]
- AML Minimal Residual Disease Table [NCIt concept]
- AML Molecular Analysis Table [NCIt concept]
- CPTAC Acute Myeloid Leukemia Baseline Form [NCIt concept]
- CPTAC Baseline Medical Forms Terminology [NCIt concept]
- CPTAC Terminology [NCIt concept]
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Disease Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NICHD Terminology [NCIt concept]
- Pediatric Hematology-Oncology Terminology [NCIt concept]
cytogenetic_abnormality_involves_chromosome
- Human Chromosome 11 [NCIt concept]
is_molecular_abnormality_of_disease
- Acute Myeloid Leukemia with KMT2A Rearrangement [NCIt concept]
- Acute Myeloid Leukemia with a Variant KMT2A Rearrangement [NCIt concept]
- Acute Myeloid Leukemia with t(10;11)(p12.3;q23.3); MLLT10-KMT2A [NCIt concept]
- Acute Myeloid Leukemia with t(10;11)(q21.3;q23.3); TET1-KMT2A [NCIt concept]
- Acute Myeloid Leukemia with t(11;19)(q23.3;p13.1); KMT2A-ELL [NCIt concept]
- Acute Myeloid Leukemia with t(11;19)(q23.3;p13.3); KMT2A-MLLT1 [NCIt concept]
- Acute Myeloid Leukemia with t(4;11)(q21.3;q23.3); AFF1-KMT2A [NCIt concept]
- Acute Myeloid Leukemia with t(6;11)(q27;q23.3); MLLT4-KMT2A [NCIt concept]
- Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A [NCIt concept]
- Adult Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A [NCIt concept]
- B Acute Lymphoblastic Leukemia with t(4;11)(q21;23.3); KMT2A-AFF1 [NCIt concept]
- B Acute Lymphoblastic Leukemia with t(v;11q23.3); KMT2A Rearranged [NCIt concept]
- B Lymphoblastic Leukemia/Lymphoma with t(v;11q23.3); KMT2A Rearranged [NCIt concept]
- Childhood Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A [NCIt concept]
- Infant Acute Lymphoblastic Leukemia with KMT2A Rearrangement [NCIt concept]
- Mixed Phenotype Acute Leukemia with KMT2A Rearrangement [NCIt concept]
- Recurrent Acute Myeloid Leukemia with KMT2A Rearrangement [NCIt concept]
- Recurrent Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A [NCIt concept]
is_not_molecular_abnormality_of_disease
- Infant Acute Lymphoblastic Leukemia without KMT2A Rearrangement [NCIt concept]
molecular_abnormality_involves_gene
- KMT2A Gene [NCIt concept]

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