Mixed Phenotype Acute Leukemia with KMT2A Rearrangement

Preferred Label : Mixed Phenotype Acute Leukemia with KMT2A Rearrangement;

NCIt synonyms : Mixed Phenotype Acute Leukemia with t(v;11q23); MLL Rearranged; Mixed Phenotype Acute Leukemia with t v 11q23 MLL Rearranged; MPAL with t(v;11q23.3); KMT2A Rearranged; MPAL, with t(v;11q23.3); KMT2A Rearranged; Mixed Phenotype Acute Leukemia with t(v;11q23.3); MLL Rearranged; Mixed-Phenotype Acute Leukemia with KMT2A Rearrangement; Mixed Phenotype Acute Leukemia with t(v;11q23.3); KMT2A Rearranged;

NCIt definition : A rare mixed phenotype acute leukemia in which the blasts carry a translocation between the KMT2A gene at 11q23.3 and another gene partner. The prognosis is usually unfavorable.;

Neoplastic status : Malignant;

ICD-O code : 9807/3;

Details

Origin ID

C82203;

UMLS CUI

C2826048;

Currated CISMeF NLP mapping
- Mixed phenotype acute leukemia with t(v;11q23); MLL rearranged (morphologic abnormality) [SNOMED CT concept]
Disease may have findings
- Granulocytopenia [NCIt concept]
- Ineffective Hematopoiesis [NCIt concept]
- Thrombocytopenia [NCIt concept]
- Unfavorable Clinical Outcome [NCIt concept]
Has associated anatomic sites
- Hematopoietic and Lymphatic System [NCIt concept]
Has cytogenetic abnormalities
- t(v;11q23.3) [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Mixed phenotype acute leukemia with t(v;11q23); MLL rearranged (morphologic abnormality) [SNOMED CT concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology Terminology [NCIt concept]
- Mapped ICDO3.1 Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology Terminology [NCIt concept]
- Mapped ICDO3.2 Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Blasts Expressing CD56 and Immature T-Cell Markers Present [NCIt concept]
- Chronic Clinical Course [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_has_abnormal_cell
- Leukemic Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Blast [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_finding
- Blasts of Mixed Phenotype Present [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Recurrent Genetic Abnormalities Present [NCIt concept]
disease_has_molecular_abnormality
- KMT2A Gene Rearrangement [NCIt concept]
disease_has_normal_cell_origin
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Multipotent Bone Marrow Stem Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_mapped_to_gene
- KMT2A Gene [NCIt concept]
disease_may_have_associated_disease
- Anemia [NCIt concept]
pathogenesis_of_disease_involves_gene
- KMT2A Gene [NCIt concept]
- KMT2A wt Allele [NCIt concept]

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