Infant Acute Lymphoblastic Leukemia with KMT2A Rearrangement

Preferred Label : Infant Acute Lymphoblastic Leukemia with KMT2A Rearrangement;

NCIt related terms : Infant ALL with MLL Rearrangement; Infant Acute Lymphoblastic Leukemia with MLL Gene Rearrangement; Infant Acute Lymphoblastic Leukemia with MLL Rearrangement;

NCIt definition : An acute lymphoblastic leukemia with rearrangement of the KMT2A gene that occurs in infancy.;

Alternative definition : NICHD: A type of acute lymphoblastic leukemia that is seen more frequently in infants younger than six months of age, as compared to those between six months of age and one year; it is characterized by very high white blood cell counts and increased incidence of central nervous system involvement.;

Neoplastic status : Malignant;

Details

Origin ID

C122617;

UMLS CUI

C4054729;

Disease excludes abnormal cell
- Leukemic Plasma Cell [NCIt concept]
Disease excludes normal cell origin
- Myeloid Cell [NCIt concept]
Disease may have findings
- Hepatomegaly [NCIt concept]
- Lymphadenopathy [NCIt concept]
Has associated anatomic sites
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- Cellosaurus Disease Terminology [NCIt concept]
- Cellosaurus Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
- NICHD Terminology [NCIt concept]
- Pediatric Hematology-Oncology Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Chronic Clinical Course [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_has_abnormal_cell
- Abnormal Lymphocyte [NCIt concept]
- Leukemic Cell [NCIt concept]
- Leukemic Lymphocyte [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Lymphoblast [NCIt concept]
- Neoplastic Lymphocyte [NCIt concept]
disease_has_finding
- Childhood Lesion [NCIt concept]
- Infantile Lesion [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
disease_has_molecular_abnormality
- KMT2A Gene Rearrangement [NCIt concept]
disease_has_normal_cell_origin
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Lymphoblast [NCIt concept]
- Lymphocyte [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
- Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]
disease_mapped_to_gene
- KMT2A Gene [NCIt concept]
disease_may_have_molecular_abnormality
- Clonal T-Cell Receptor Beta Chain Gene Rearrangement [NCIt concept]
- Clonal T-Cell Receptor Gamma Chain Gene Rearrangement [NCIt concept]
pathogenesis_of_disease_involves_gene
- KMT2A Gene [NCIt concept]
- KMT2A wt Allele [NCIt concept]

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