B Acute Lymphoblastic Leukemia with t(v;11q23.3); KMT2A Rearranged

Preferred Label : B Acute Lymphoblastic Leukemia with t(v;11q23.3); KMT2A Rearranged;

NCIt synonyms : B-ALL with t(v;11q23.3)/KMT2A Rearranged; B Acute Lymphoblastic Leukemia with t(v;11q23.3); MLL Rearranged; B-Acute Lymphoblastic Leukemia with t(v;11q23.3); MLL Rearranged; B Acute Lymphoblastic Leukemia with t v 11q23 MLL Rearranged; B-Cell Acute Lymphoblastic Leukemia with t(v;11q23.3); MLL Rearranged; B-ALL with t(v;11q23.3); KMT2A Rearranged; B-Acute Lymphoblastic Leukemia with t(v;11q23.3); KMT2A Rearranged; B Acute Lymphoblastic Leukemia with KMT2A Rearrangement; B-Acute Lymphoblastic Leukemia with KMT2A Rearrangement;

NCIt definition : A B-cell acute leukemia characterized by the presence of lymphoblasts that carry a translocation between the KMT2A gene at 11q23.3 and another gene partner resulting in the production of an KMT2A related fusion protein. It is the most commonly seen leukemia in the pediatric population under the age of one year. The prognosis is unfavorable.;

Neoplastic status : Malignant;

Details

Origin ID

C80342;

UMLS CUI

C2698308;

DO Cross reference
- B-lymphoblastic leukemia/lymphoma KMT2A rearranged [DO Concept]
Disease excludes abnormal cell
- Leukemic Plasma Cell [NCIt concept]
- Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell [NCIt concept]
Disease excludes normal cell origin
- Mature B-Lymphocyte [NCIt concept]
- Myeloid Cell [NCIt concept]
Disease may have findings
- Bone Pain [NCIt concept]
- Extensive Bone Marrow and Blood Involvement [NCIt concept]
- Granulocytopenia [NCIt concept]
- Hepatomegaly [NCIt concept]
- Lymphadenopathy [NCIt concept]
- Splenomegaly [NCIt concept]
- Thrombocytopenia [NCIt concept]
- Unfavorable Clinical Outcome [NCIt concept]
Has associated anatomic sites
- Hematopoietic and Lymphatic System [NCIt concept]
Has cytogenetic abnormalities
- t(v;11q23.3) [NCIt concept]
See also inter- (CISMeF)
- acute lymphoblastic leukemia with MLL [Disease (Nov.)]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- Cellosaurus Disease Terminology [NCIt concept]
- Cellosaurus Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Blasts of Mixed Phenotype Present [NCIt concept]
- Chronic Clinical Course [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_has_abnormal_cell
- Abnormal Lymphocyte [NCIt concept]
- Leukemic Cell [NCIt concept]
- Leukemic Lymphocyte [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic B-Lymphoblast [NCIt concept]
- Neoplastic B-Lymphocyte [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Lymphoblast [NCIt concept]
- Neoplastic Lymphocyte [NCIt concept]
disease_has_finding
- Malignant Cellular Infiltrate [NCIt concept]
- Recurrent Genetic Abnormalities Present [NCIt concept]
disease_has_molecular_abnormality
- Clonal Immunoglobulin Gene Rearrangement [NCIt concept]
- KMT2A Gene Rearrangement [NCIt concept]
disease_has_normal_cell_origin
- B-Lymphocyte [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Lymphoblast [NCIt concept]
- Lymphocyte [NCIt concept]
- Precursor B-Lymphoblast [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
- Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]
disease_mapped_to_gene
- KMT2A Gene [NCIt concept]
disease_may_have_associated_disease
- Anemia [NCIt concept]
disease_may_have_molecular_abnormality
- Clonal Immunoglobulin Heavy Chain Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Kappa Light Chain Gene Rearrangement [NCIt concept]
- Clonal T-Cell Receptor Beta Chain Gene Rearrangement [NCIt concept]
- Clonal T-Cell Receptor Gamma Chain Gene Rearrangement [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients