Acute Myeloid Leukemia with a Variant KMT2A Rearrangement

Preferred Label : Acute Myeloid Leukemia with a Variant KMT2A Rearrangement;

NCIt synonyms : Acute Myeloid Leukemia with 11q23 MLL Abnormalities; Acute Myeloid Leukemia with a Variant MLL Translocation; Acute Myeloid Leukemia with a Variant MLL Rearrangement; Acute Myeloid Leukemia with Other KMT2A Rearrangements; AML with Other KMT2A Rearrangements; Acute Myeloid Leukemia with Variant MLL Rearrangement;

NCIt related terms : AML with Variant MLL Translocations; Acute Myeloid Leukemia with Variant MLL Translocations;

NCIt definition : A term referring to acute myeloid leukemias with rearrangement of the KMT2A gene that results in translocations with various genes other than the MLLT3 (AF9) gene.;

Alternative definition : NICHD: A term referring to acute myeloid leukemias with rearrangement of the MLL gene which results in translocations with more than 50 partner genes other than the MLLT3 (AF9) gene.;

Neoplastic status : Malignant;

ICD-O code : 9897/3;

Details

Origin ID

C6924;

UMLS CUI

C2825116;

Disease excludes abnormal cell
- Neoplastic Lymphoblast [NCIt concept]
Disease excludes normal cell origin
- Lymphocyte [NCIt concept]
Disease may have findings
- Hypercellular Bone Marrow [NCIt concept]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Has cytogenetic abnormalities
- Chromosomal Rearrangement [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
associated_with_malfunction_of_gene_product
- Protein ENL [NCIt concept]
concept_is_in_subset
- NCIt Neoplasm Core Terminology [NCIt concept]
- NICHD Terminology [NCIt concept]
- Pediatric Hematology-Oncology Terminology [NCIt concept]
disease_excludes_cytogenetic_abnormality
- MLLT3 Gene Rearrangement [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Chronic Clinical Course [NCIt concept]
- Cytogenetic Abnormalities Not Detected [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_has_abnormal_cell
- Leukemic Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloblast [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
disease_has_finding
- Blasts 10 Percent or More of Bone Marrow Nucleated Cells [NCIt concept]
- Blasts 10 Percent or More of Peripheral Blood White Cells [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Recurrent Genetic Abnormalities Present [NCIt concept]
disease_has_molecular_abnormality
- Fusion Protein Expression [NCIt concept]
- KMT2A Gene Rearrangement [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Multipotent Bone Marrow Stem Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_mapped_to_gene
- KMT2A Gene [NCIt concept]
pathogenesis_of_disease_involves_gene
- MLL/MLLT1 Fusion Gene [NCIt concept]
- MLL/MLLT10 Fusion Gene [NCIt concept]
- MLLT10/CLP1 Fusion Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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