" /> Protein ENL - CISMeF





Preferred Label : Protein ENL;

NCIt synonyms : YEATS Domain-Containing Protein 1; MLLT1; Trithorax Homolog 1; ENL Protein; ENL;

NCIt definition : Protein ENL (559 aa, 62 kDa) is encoded by the human MLLT1 gene. This protein is involved in transcription.;

NCIt note : ENL Protein is similar to MLLT3/AF9 (Human), TFG3/ANC1 (Yeast), and trithorax (Drosophila), contains nuclear targeting sequences, serine- and proline-rich regions, and stretches abundant in basic amino acids, and appears capable of transcriptional transactivation in lymphoid and myeloid cells. The C-terminal 90-aa of MLLT1 are required for activation of transcription. A common acute leukemia chromosomal translocation t(11;19)(q23;p13.3) involves MLL/HRX and MLLT1 that results in a rogue chimeric activator protein containing the MLL N-terminal AT-hook motifs.;

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31/07/2025


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