MLL/MLLT10 Fusion Gene

Preferred Label : MLL/MLLT10 Fusion Gene;

NCIt synonyms : MLL/AF10 Fusion Gene; AF10/MLL Fusion Gene; MLL-MLLT10 Fusion Gene; MLL-AF10 Fusion Gene; MLL::MLLT10 Fusion Gene; KMT2A::MLLT10 Fusion Gene;

NCIt definition : A fusion gene that results from a chromosomal translocation t(10;11)(p12;q23) which fuses the 5' half of the MLL gene to the 3' half of the MLLT10 gene. This rearrangement is associated with acute myeloid leukemia.;

NCIt note : The presence of this fusion gene is associated with a poor prognosis.; The translocation t(10;11)(p12;q23) is frequently accompanied by an inversion inv(11)(q13q23) which results in an MLLT10/CLP1 fusion gene.;

Details

Origin ID

C99347;

UMLS CUI

C1865579;

Automatic exact mappings (from CISMeF team)
- Lysine-specific methyltransferase 2a [OMIM Phenotype]
- Mllt10 histone lysine methyltransferase dot1l cofactor [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- MLL/MLLT10 Fusion Protein [NCIt concept]
gene_involved_in_molecular_abnormality
- KMT2A-MLLT10 Fusion Protein Expression [NCIt concept]
- t(10;11)(p12;q23) [NCIt concept]
gene_involved_in_pathogenesis_of_disease
- Acute Myeloid Leukemia with a Variant KMT2A Rearrangement [NCIt concept]
- Acute Myeloid Leukemia with t(10;11)(p12.3;q23.3); MLLT10-KMT2A [NCIt concept]
gene_mapped_to_disease
- Acute Myeloid Leukemia with t(10;11)(p12.3;q23.3); MLLT10-KMT2A [NCIt concept]
related_to_genetic_biomarker
- KMT2A Gene [NCIt concept]
- MLLT10 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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