" /> Protein PML - CISMeF





Preferred Label : Protein PML;

NCIt synonyms : Inducer of Promyelocytic Leukemia Protein; TRIM19; Transcription Factor PML; Tripartite Motif-Containing Protein 19; RING Finger Protein 71; Tripartite Motif Protein TRIM19; Tripartite Motif Protein-TRIM19; RING-Type E3 SUMO Transferase PML; E3 SUMO-Protein Ligase PML; EC 2.3.2.-;

NCIt related terms : PML; PROMYELOCYTIC LEUKEMIA PROTEIN; PML Protein;

NCIt definition : Protein PML (882 aa, 98 kDa) is encoded by the human PML gene. This protein plays a role in both transcriptional regulation and PML body formation.;

Alternative definition : CDISC: A nucleoprotein that functions as a transformation and cell growth suppressor, and is aberrantly expressed in promyelocytic leukemia cells. It can be considered as an autoantigen and is commonly associated with primary biliary liver cirrhosis and other autoimmune liver diseases.;

NCIt note : Tripartite Motif Protein TRIM19 is a transcription factor and tumor suppressor that regulates the p53 response to oncogenic signals, interacts with SIRT1, and contains a TRIM motif: 3 zinc-binding domains, a RING-type zinc finger, a B-box type 1 zinc finger, a B-box type 2 zinc finger, and a coiled-coil region.;

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18/06/2025


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