TRIM Family - CISMeF

Preferred Label : TRIM Family;

NCIt definition : Genes belonging to this family are implicated in several inherited human diseases (Familial Mediterranean Fever, X-linked Opitz/GBBB syndrome, and Mulibrey nanism) and in tumorigenesis. The TRIM proteins have a strong self-association ability that is mediated by their coiled-coil region. This property results in the formation of large protein complexes that identify diverse discrete sub-cellular structures. The formation of these cellular compartments is strictly dependent on the integrity of the Tripartite Motif. The TRIM proteins might play a role in cell sub-compartmentalization.;

Details

Origin ID

C21255;

UMLS CUI

C1336673;

Biochemical function of gene products
- Protein PML [NCIt concept]
- Transcription Intermediary Factor 1-Alpha [NCIt concept]
- Transcriptional Intermediary Factor 1-Beta [NCIt concept]
- Tripartite Motif-Containing Protein 16 [NCIt concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_product_has_structural_domain_or_motif
- TRIM Motif [NCIt concept]
is_chemical_classification_of_gene_product
- E3 Ubiquitin-Protein Ligase TRIM33 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIM36 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIM37 [NCIt concept]
- Tripartite Motif-Containing Protein 5 [NCIt concept]

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