" /> Transcription Factor PU.1 - CISMeF





Preferred Label : Transcription Factor PU.1;

NCIt synonyms : PU.1 Transcription Factor; 31 kDa-Transforming Protein; SPI1; SPI1 Protein; SPI1 Gene Product; Hematopoietic Transcription Factor PU.1; PU-1 Transcription Factor;

NCIt definition : Transcription factor PU.1 (270 aa, 31 kDa) is encoded by the human SPI1 gene. This protein plays a role in transcriptional regulation in hematopoietic cells.;

NCIt note : Normally expressed in all hematopoietic lineages, except T-cells, the ETS-domain PU.1 Transcription Factor is essential for development of myeloid (osteoclast progenitors) and B-lymphoid cells. Graded PU.1 expression appears to specify distinct cell fates in the hematopoietic system; a low concentration induces the B-cell fate, while a high concentration promotes macrophage differentiation. PU.1 is thought to regulate transcription of FMS and CD18/11B, proteins central to the osteoclast phenotype, and is required for p47-phox promoter activity in myeloid cells. PU.1 expression is increased with the induction of osteoclastogenesis by 1, 25-dihydroxyvitamin D3. (OMIM); Transcription factor PU.1 binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3'). (UniProt);

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
18/05/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.