ETS Domain - CISMeF

Preferred Label : ETS Domain;

NCIt definition : Usually C-terminal, the conserved ETS (Erythroblast Transformation Specific) Domain of 85-90 amino acids, rich in positively-charged and aromatic residues, binds to purine-rich DNA with a GGAA/T core. Identified in many transcription factors, many ETS-proteins modulate gene expression through protein-protein interactions with other transcriptional factors and co-factors. Most ETS-proteins are nuclear targets of RAS-MAPK signaling; some affect cell proliferation or apoptosis-related genes. Several are expressed in specific cell lineages to regulate development and differentiation. Deregulated ETS-gene expression or chimeric ETS-proteins are associated with leukemias, some tumors, invasion and metastasis. (NCI);

Details

Origin ID

C13719;

UMLS CUI

C1512142;

Automatic exact mappings (from CISMeF team)
- ETS Motif [MeSH Descriptor]
Semantic type(s)
- Amino Acid Sequence [UMLS semantic type]
UMLS correspondences (same concept)
- ETS Motif [MeSH Descriptor]
is_structural_domain_or_motif_of_gene_product
- ETS Domain-Containing Protein Elk-1 [NCIt concept]
- ETS Domain-Containing Protein Elk-3 [NCIt concept]
- ETS Domain-Containing Protein Elk-4 [NCIt concept]
- ETS Domain-Containing Transcription Factor ERF [NCIt concept]
- ETS Family Protein [NCIt concept]
- ETS Homologous Factor [NCIt concept]
- ETS Translocation Variant 1 [NCIt concept]
- ETS Translocation Variant 3 [NCIt concept]
- ETS Translocation Variant 4 [NCIt concept]
- ETS Translocation Variant 5 [NCIt concept]
- ETS-Related Transcription Factor Elf-3 [NCIt concept]
- ETS-Related Transcription Factor Elf-4 [NCIt concept]
- Friend Leukemia Integration 1 Transcription Factor [NCIt concept]
- MNX1/ETV6 Fusion Protein [NCIt concept]
- Protein C-ets-1 [NCIt concept]
- Protein C-ets-2 [NCIt concept]
- Protein FEV [NCIt concept]
- SAM Pointed Domain-Containing Ets Transcription Factor [NCIt concept]
- Transcription Factor ETV6 [NCIt concept]
- Transcription Factor PU.1 [NCIt concept]
- Transcription Factor Spi-B [NCIt concept]
- Transcriptional Regulator ERG [NCIt concept]

Keyword's position in hierarchy(ies) :

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