Transcriptional Regulator ERG

Preferred Label : Transcriptional Regulator ERG;

NCIt synonyms : ERG; ERG1; ERG2; Transforming Protein ERG; Transforming Protein-ERG;

NCIt definition : Transcriptional regulator ERG (486 aa, 55 kDa) is encoded by the human ERG gene. This protein plays a role in protein-protein interactions and transcriptional regulation.;

NCIt note : A member of the ETS family of transcription factors closely related to FLI1, Transforming Protein ERG shows homology to two domains of the ETS oncogene. ERG1 and ERG2 are products of alternative splicing and polyadenylation, as well as translation initiation. ERG2 is a nuclear phosphoprotein that binds to purine-rich sequences. Like other ETS proteins, ERG2 is a sequence-specific DNA-binding protein and expressed at higher levels in early myeloid cells than in mature lymphoid cells. ERG2 acts as a regulator of genes required for maintenance and/or differentiation of early hematopoietic cells. (OMIM);

Details

Origin ID

C18557;

UMLS CUI

C0295291;

OMIM relation
- Ets transcription factor erg [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ERG protein, human [MeSH Supplementary Concept]
- ERG protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ERG Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- ETS Family Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- ETS Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- DNA Binding [NCIt concept]
- Hematopoietic Process [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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